abstract：:The pharmacokinetics of melatonin during the day-time has been studied in 4 healthy subjects after a bolus i.v. injection of 5 or 10 micrograms/person and after a 5 h infusion of 20 micrograms per person in 6 healthy subjects. In addition, a pinealomectomized patient whose nocturnal plasma melatonin had been abolished...

journal_title：European journal of clinical pharmacology

authors： Mallo C,Zaĭdan R,Galy G,Vermeulen E,Brun J,Chazot G,Claustrat B

更新日期：1990-01-01 00:00:00

abstract：:The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-veno...

journal_title：European journal of clinical pharmacology

authors： Madsen PL,Vorstrup S,Schmidt JF,Paulson OB

更新日期：1990-01-01 00:00:00

abstract：:Factors which might affect paracetamol disposition have been studied in a heterogenous group of patients in need of mild analgesia in an intensive care unit. Following oral administration of 1 g of paracetamol, plasma and urinary concentrations of the parent compound and metabolites were assessed by HPLC. The renal cl...

journal_title：European journal of clinical pharmacology

authors： Kietzmann D,Bock KW,Krähmer B,Kettler D,Bircher J

更新日期：1990-01-01 00:00:00

abstract：:The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males. Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, ...

journal_title：European journal of clinical pharmacology

authors： Krämer BK,Häussler M,Ress KM,Müller GA,Burger KJ,Risler T

更新日期：1990-01-01 00:00:00

abstract：:The influence of a diet deficient in energy or protein on hepatic oxidation (Phase I reactions) and glucuronidation (Phase II reactions) in man has been examined. Nine healthy volunteers were fed an energy deficient diet (daily energy intake 4.3 MJ; daily protein intake 0.94 g/kg) and a protein deficient diet (daily e...

journal_title：European journal of clinical pharmacology

authors： Hamberg O,Ovesen L,Dorfeldt A,Loft S,Sonne J

更新日期：1990-01-01 00:00:00

abstract：:In a cross-over study of six healthy male volunteers, 500 mg theophylline was administered either as plain tablets or in a sustained release preparation. On each occasion 2 g of non-enteric coated sulphasalazine was administered simultaneously as the time of appearance of sulphapyridine, the product of hydrolysis, in ...

journal_title：European journal of clinical pharmacology

authors： Sommers DK,Meyer EC,van Wyk M,Moncrieff J

更新日期：1990-01-01 00:00:00

abstract：:The aim of laboratory screening in Phase I is to exclude subjects with subclinical illness, who might be at increased risk in the study, and who might also adversely influence interpretation of the results. A new method for laboratory screening, based on Bayesian probability theory, is proposed, which consists of: 1. ...

journal_title：European journal of clinical pharmacology

authors： Sibille M,Vital Durand D

更新日期：1990-01-01 00:00:00

abstract：:This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were ...

journal_title：European journal of clinical pharmacology

authors： Peterson GM,Boyle RR,Francis HW,Oliver NW,Paterson J,von Witt RJ,Taylor GR

更新日期：1990-01-01 00:00:00

abstract：:To evaluate the influence of the stomach and the cholinergic system on gallbladder contraction induced by physiological stimuli, the reduction in gallbladder volume in 7 healthy volunteers has been studied by real-time ultrasonography after the oral and intraduodenal administration of olive oil, preceded by pretreatme...

journal_title：European journal of clinical pharmacology

authors： Marzio L,Di Felice F,Celiberti V,Pieramico O,Grossi L,DiGioacchino M,Imbimbo BP,Cuccurullo F

更新日期：1990-01-01 00:00:00

abstract：:Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension. The effects on blood pressure were measured (Riva Rocci) before medication and after 2 h with the patient in a lying and standing position after 4 weeks of...

journal_title：European journal of clinical pharmacology

authors： Krönig B,Widmann L,Staiger C,Machwirth M,Stienen U,Hennig M,Müller-Beckmann B

更新日期：1990-01-01 00:00:00

abstract：:In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be highe...

journal_title：European journal of clinical pharmacology

authors： Van Bortel LM,Schiffers PM,Böhm RO,Mooij JM,Rahn KH,Struyker Boudier HA

更新日期：1990-01-01 00:00:00

abstract：:The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62-79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg daily for 8 weeks. Periphe...

journal_title：European journal of clinical pharmacology

authors： Nagakawa Y,Akedo Y,Kaku S,Orimo H

更新日期：1990-01-01 00:00:00

abstract：:The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the ...

journal_title：European journal of clinical pharmacology

authors： George S,McBurney A,Cole A

更新日期：1990-01-01 00:00:00

abstract：:The pharmacokinetics of phenytoin was studied in 66 epileptic Chinese children and adults. The data were analysed by the population approach, using the non-linear mixed effect model, in the MULTI (ELS) program. There was no age or gender-related effect on either the apparent maximum elimination rate (kmax) or Michaeli...

journal_title：European journal of clinical pharmacology

authors： Chan E,Ti TY,Lee HS

更新日期：1990-01-01 00:00:00

abstract：:The acute effects on monophasic action potentials (MAP), QT interval, and right ventricle effective refractory period (V-ERP) of propranolol 0.2 mg.kg-1 body weight have been studied in 10 patients with coronary artery disease. The median duration of MAP at 90% repolarization (MAP90) was shortened from 238 to 228 ms a...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP

更新日期：1990-01-01 00:00:00

abstract：:In Belgium, all dispensed drugs are provided with package inserts. Traditional physician-orientated inserts are gradually being replaced by patient package inserts (PPIs). The present survey is focused on the use of inserts for antihypertensive drugs and their impact on the reported occurrence and attribution of adver...

journal_title：European journal of clinical pharmacology

authors： Van Haecht CH,Vander Stichele R,Bogaert MG

更新日期：1990-01-01 00:00:00

abstract：:The role of mental stress in the development of hypertension and coronary heart disease remains uncertain. Its effects are likely to depend on an interaction of at least three factors: the nature of the stressor, its perception by the individual, and the individual's physiological susceptibility. This type of interact...

journal_title：European journal of clinical pharmacology

authors： Pickering TG

更新日期：1990-01-01 00:00:00

abstract：:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and ...

journal_title：European journal of clinical pharmacology

authors： Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

更新日期：1990-01-01 00:00:00

abstract：:Seventeen patients underwent tonsillectomy 55-120 min after receiving oral phenoxymethylpenicillin 12.5 mg/kg bodyweight. The penicillin concentration in serum and tonsillar tissue in each patient was determined by a microbial assay. In 9 patients with tonsillar hyperplasia, but with no prior history of tonsillitis, t...

journal_title：European journal of clinical pharmacology

authors： Roos K,Brorson JE

更新日期：1990-01-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced o...

journal_title：European journal of clinical pharmacology

authors： Lang CC,Lau CS,Belch JJ,Struthers AD

更新日期：1990-01-01 00:00:00

abstract：:Unstable angina is a clinical syndrome characterized by increased rate and severity of angina pectoris attacks and, sometimes but not always, accompanied by ECG changes similar to those seen in coronary insufficiency. According to the present conception of the pathogenesis, ruptures at points of high-grade stenosis in...

journal_title：European journal of clinical pharmacology

authors： Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：:The efficacy of bopindolol and atenolol in the treatment of patients with chronic stable angina pectoris have been compared in a double blind, randomized study. Both bopindolol 1 mg and atenolol 100 mg for 6 weeks increased mean exercise time (25% and 22%, respectively, compared to placebo), time to angina (27% and 25...

journal_title：European journal of clinical pharmacology

authors： Fitscha P,Meisner W,Tiso B

更新日期：1990-01-01 00:00:00

abstract：:Effects on psychomotor and cognitive performance of adinazolam (15 or 30 mg), alone and in combination with ethanol (0.8 g/kg), were studied in healthy male volunteers and compared to effects of 10 mg diazepam. Adinazolam 30 mg produced relatively long-lasting impairments on tests of tracking, attention, verbal and no...

journal_title：European journal of clinical pharmacology

authors： Linnoila M,Stapleton JM,Lister R,Moss H,Lane E,Granger A,Greenblatt DJ,Eckardt MJ

更新日期：1990-01-01 00:00:00

abstract：:Twenty patients (5 females, 15 males) with severe heart failure (NYHA IV), due to coronary artery disease in 14, and congestive cardiomyopathy in 6, received an intravenous bolus of the calcium blocker nisoldipine 0.2 mg followed by a continuous infusion of 0.2 micrograms.kg-1.min-1. Haemodynamic measurements were per...

journal_title：European journal of clinical pharmacology

authors： Erlemeier HH,Kupper W,Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：:The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients. At three different times during the cycle (first, tenth and twentieth days) each subject received an i.v. infusion of 240 mg theophylline. Significant changes were found in the kinetics of theophyllin...

journal_title：European journal of clinical pharmacology

authors： Bruguerolle B,Toumi M,Faraj F,Vervloet D,Razzouk H

更新日期：1990-01-01 00:00:00

abstract：:Data on forged prescriptions in Sweden in 1982-1986 were studied as an indicator in an epidemiological survey of medication abuse. The annual number of prescription forgeries doubled during the 5-year period. Psychotropic drugs accounted for 62% and analgesics for 25% of all forgeries. Benzodiazepines were the major s...

journal_title：European journal of clinical pharmacology

authors： Bergman U,Dahl-Puustinen ML

更新日期：1989-01-01 00:00:00

abstract：:In seeking the putative mechanism of action of diethyldithiocarbamate (DTC) on the immune status of HIV infected patients, the plasma membrane fluidity of peripheral blood lymphocytes (PBL) from DTC-treated and untreated patients (CDC III-IVc1) was determined. Anisotropy values of the fluorescent probe 6-(9-anthroylox...

journal_title：European journal of clinical pharmacology

authors： Lehr HA,Zimmer JP,Hübner C,Reisinger EC,Kohlschütter A,Claussen M,Schmitz H,Dietrich M

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg.h-1 for 4 h, starting 1 to 3 h post surgery. Multiple bloo...

journal_title：European journal of clinical pharmacology

authors： Maitre PO,Funk B,Crevoisier C,Ha HR

更新日期：1989-01-01 00:00:00

abstract：:The beta-adrenoceptor blocking activity of the new Class Ic-antiarrhythmic drug diprafenone has been determined in man in comparison with that of propranolol, using the standardized isoproterenol test. Following placebo, the dose of isoproterenol which increased the heart rate by 25 beats.min-1 (CD25) was 0.84 (0.1-2....

journal_title：European journal of clinical pharmacology

authors： Wagner F,Jähnchen E,Trenk D

更新日期：1989-01-01 00:00:00

abstract：:A cross-over study of kinetics has been undertaken in 12 healthy adults volunteers using two sustained-release theophylline products that allow once a day dosing (Theo-Dur tablets and Dilatrane A.P. bead filled capsules) to compare the i.v. pharmacokinetic profiles when taken with an hyperlipidic meal and a balanced s...

journal_title：European journal of clinical pharmacology

authors： Brazier JL,Benchekroun Y,Gillet A,Andre C

更新日期：1989-01-01 00:00:00

abstract：:A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinet...

journal_title：European journal of clinical pharmacology

authors： Takagi K,Kuzuya T,Horiuchi T,Nadai M,Apichartpichean R,Ogura Y,Hasegawa T

更新日期：1989-01-01 00:00:00

abstract：:Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significant...

journal_title：European journal of clinical pharmacology

authors： Schmidt C,Gavoille R,Perez P,Schmitt J

更新日期：1989-01-01 00:00:00

abstract：:Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volu...

journal_title：European journal of clinical pharmacology

authors： Larkin JG,Macphee GJ,Beastall GH,Brodie MJ

更新日期：1989-01-01 00:00:00

abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Verbesselt R,Tjandra-Maga TB,De Schepper PJ

更新日期：1989-01-01 00:00:00

abstract：:Oxitropium bromide (OXBR) is a new anticholinergic drug, which is expected to be useful in the treatment of nocturnal asthma. The only pharmacokinetic data were obtained with the 14C-labelled compound. A sensitive radioreceptor assay for the determination of unlabelled OXBR in plasma was developed, based on competitio...

journal_title：European journal of clinical pharmacology

authors： Ensing K,de Zeeuw RA,in 't Hout WG,Cornelissen PJ

更新日期：1989-01-01 00:00:00

abstract：:To assess the duration of the antihypertensive effect of the dihydropiridine calcium antagonist felodipine in conventional (C-F) and slow-release (ER-F) formulations, 12 patients with essential hypertension underwent ambulatory blood pressure monitoring (ABPM) at the end of a 2-week treatment period with C-F 5 mg b.d....

journal_title：European journal of clinical pharmacology

authors： Porcellati C,Verdecchia P,Gatteschi C,Benemio G,Guerrieri M,Boldrini F,Pollavini G

更新日期：1989-01-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：:The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled n...

journal_title：European journal of clinical pharmacology

authors： Guerret M,Cheymol G,Hubert M,Julien-Larose C,Lavene D

更新日期：1989-01-01 00:00:00

abstract：:The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakal...

journal_title：European journal of clinical pharmacology

authors： Ferrier CP,Kurtz A,Lehner P,Shaw SG,Pusterla C,Saxenhofer H,Weidmann P

更新日期：1989-01-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00